Vegetos
(An International Journal of Plant Research & Biotechnology)
(eISSN: 2229-4473)
Flavonoids as antioxidants and anti-inflammatory agents in cancer prevention
*Article not assigned to an issue yet
Rawat Gaurav, Geetha S. J., Pandit Soumya, Rajamohan Natarajan, Joshi Sanket J.
Review Articles | Published: 08 April, 2026
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Last Page: 0
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Keywords: Flavonoids, Plant-derived polyphenolics, Antioxidants, Anti-inflammatory, Cancer prevention
Abstract
Flavonoids are a diverse class of plant-derived polyphenolic compounds recognized for their potent antioxidant and anti-inflammatory properties, with significant potential in cancer prevention. Abundant in fruits, vegetables, tea, wine, and legumes, flavonoids mitigate oxidative stress and chronic inflammation through free radical scavenging, metal chelation, modulation of endogenous antioxidant enzymes, and suppression of pro-inflammatory mediators. Mechanistically, they regulate multiple cancer-related pathways, leading to cell cycle arrest, apoptosis induction, inhibition of angiogenesis, and suppression of metastasis. Additionally, flavonoids influence epigenetic modifications and target cancer stem cells, offering a multifaceted approach to disrupting tumor initiation and progression. Preclinical and epidemiological studies link high flavonoid intake to reduced incidence of breast, prostate, colorectal, and lung cancers, while clinical trials with compounds such as quercetin, epigallocatechin gallate, genistein, and anthocyanins demonstrate biomarker modulation and potential therapeutic synergy with conventional treatments. However, challenges including poor bioavailability, rapid metabolism, and variable patient response limit clinical translation. Advances in nano formulations, structural optimization, and personalized nutrition strategies promise to enhance their efficacy. This review consolidates current knowledge on flavonoids’ antioxidant and anti-inflammatory mechanisms, molecular targets, and translational potential, highlighting their role as natural, multi-targeted agents in dietary-based cancer prevention and adjunctive therapy.
References
Abbas S, Shahbaz M, Ali A et al (2025) Casticin: a natural flavonoid with promising pharmacological and biological activities. Fitoterapia, p106746
Abd El-Hack ME, Aldhalmi AK, Kamal M, et al (2025) Flavonoids as a phytobiotic agent: sources, classifications, biological benefits, and useful impacts on broilers and layers. Phytochem Rev, pp 1–27
Al Hoque A, Begum S, Dutta D (2025) Occurrence, chemical nature, and medicinal benefits of flavonoids-rutin, kaempferol, quercetin, anthocyanidins, catechins, and flavones. dietary supplements and nutraceuticals. Springer Nature, Singapore, pp 1–24
Al-Dissi A, El-Sayed EM, Abdo SA, Al-Qudah MA (2019) The anti-angiogenic activity of selected dietary phytochemicals: a review. Pharmacogn Rev 13(25):11–20. https://www.phcogrev.com/article/2019/13/25/1013PR06
Alharbi HOA, Alshebremi M, Babiker AY, Rahmani AH (2025) The role of quercetin, a flavonoid in the management of pathogenesis through regulation of oxidative stress, inflammation, and biological activities. Biomolecules 15(1):151
Al-Khayri JM, Sahana GR, Nagella P, et al (2022) Flavonoids as potential anti-inflammatory molecules: a review. In:: Lucie 27:2901. https://doi.org/10.3390/molecules27092901
Arora J, Sharma V, Ramawat KG (2025) Isoflavonoids. Natural products: phytochemistry, botany, metabolism of alkaloids, phenolics and terpenes. Springer, Heidelberg, pp 1–22
Arts IC, Hollman PC (2005) Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 81(suppl1):317S–325S. https://pubmed.ncbi.nlm.nih.gov/15640498/
Cai Y, Liang YC, Hu XY, et al (2025) Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007–2010. Sci Rep 15(1):4423
Chávez-González ML, Sepúlveda L, Verma DK et al (2020) Conventional and emerging extraction processes of flavonoids. Processes 8:434. https://doi.org/10.3390/pr8040434
Chen Y, Yu D, Zhu D et al (2025) Exploring alkaloids and flavonoids from natural sources: emerging natural agents for inhibiting cervical cancer progression through apoptosis induction, anti-inflammatory effects, and oxidative stress reduction. Pathology-Research and Practice, p 156092
Ciumărnean L, Milaciu MV, †, Runcan O, et al (2020) The effects of flavonoids in cardiovascular diseases. In: Celestino Santos-Buelga (ed) Molecules [Journal-article]. https://doi.org/10.3390/molecules25184320
Dias MC, Pinto DCGA, Silva AMS (2021) Plant flavonoids: chemical characteristics and biological activity. Molecules 5377. https://doi.org/10.3390/molecules26175377
Działo M, Mierziak J, Korzun U, Geppert D (2016) Flavonoids as anticancer agents molecules 21(7):903. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272517/
Forman HJ, Zhang H (2021) Targeting the Nrf2 pathway in cancer: a double-edged sword. J Funct Foods 81:104443. https://pubmed.ncbi.nlm.nih.gov/33732049/
Galati G, O’Brien PJ (2004) Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37(3):287–303. https://doi.org/10.1016/j.freeradbiomed.2004.04.034
García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA (2009) Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 58(9):537–552. https://doi.org/10.1007/s00011-009-0037-3
Gayi BK, Aiduenu AF, Dofuor AK et al (2026) Significance and implications of prostate cancer: critical overview for future directions in Africa. Cancer Invest 1–22. https://doi.org/10.1080/07357907.2025.2598046
Giri S, Saha P (2025) Anti-inflammatory flavonoids found in medicinal plants of acanthaceae family. Indian J Nat Prod Resour (IJNPR)[Formerly Nat Prod Radiance (NPR)] 16(2):209–226
Gong S, Fei Y (2025) Moderate dietary flavonoid intake associated with lower prevalence of Parkinson’s disease: data from the NHANES 2007–2010 and 2017–2018. Neurol Res 47(5):406–419
Griffiths K, Aggarwal B, Singh R, Buttar H, Wilson D, De Meester F (2016) Food antioxidants and their anti-inflammatory properties: a potential role in cardiovascular diseases and cancer prevention. Diseases 4(3):28. https://doi.org/10.3390/diseases4030028
Hashim NT, Babiker R, Chaitanya NC et al (2025) New insights in natural bioactive compounds for periodontal disease: Advanced molecular mechanisms and therapeutic potential. Molecules 30(4):807
He J, Giusti MM (2010) Anthocyanins: Natural colorants with health-promoting properties. Annual Rev Food Sci Technol 1:163–187. https://doi.org/10.1146/annurev.food.080708.100754
Hossain MS, Wazed MA, Asha S, Amin MR, Shimul IM (2025) Dietary phytochemicals in health and disease: mechanisms, clinical evidence, and applications—a comprehensive review. Food Sci Nutr 13(3):e70101
Hu L, Luo Y, Yang J, Cheng C (2025) Botanical flavonoids: efficacy, absorption, metabolism and advanced pharmaceutical technology for improving bioavailability. Molecules 30(5):1184
Jiao Y, Li S, Wang X, Song Y, Yan Z, Li F (2018) Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Mol Med Rep 18(4):3691–3696. https://pubmed.ncbi.nlm.nih.gov/30066914/
Jomova K, Alomar SY, Valko R, Nepovimova E, Kuca K, Valko M (2025) The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases. EXCLI J 24:880–954
Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT, Lee MT (2005) The antitumor activities of flavonoids. Vivo 19(5):895–909
Kannan G, Paul BM, Thangaraj P (2025) Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review. Inflammopharmacology 33(1):145–162
Kejík Z, Kaplánek R, Masařík M, et al (2021) Iron complexes of flavonoids-antioxidant capacity and beyond. Int J Mol Sci 22(2). https://doi.org/10.3390/ijms22020646
Khan H, Ullah H, Castilho PCMF, et al (2020) Targeting NF-κB signaling pathway in cancer by dietary polyphenols. Crit Rev Food Sci Nutr 60(16):2790–2800. https://doi.org/10.1080/10408398.2019.1661827
Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J (2020) Flavonoids as anticancer agents. Nutrients 12(2):457. https://doi.org/10.3390/nu12020457
Ku Y, Ng M, Cheng S, Lo AW, Xiao Z, Shin T, Chung G, Lam H (2020) Understanding the composition, biosynthesis, accumulation and transport of flavonoids in crops for the promotion of crops as healthy sources of flavonoids for human consumption. Nutrients 12(6):1717. https://doi.org/10.3390/nu12061717
Kumar R, Kamboj N, Gunsola D, Karmakar R, Chattaraj S, Gangola S (2025) Phytonutrients: harnessing anti-inflammatory and anti-cancer potential for health benefits. Curr Res Nutr Food Sci J 13(Special Issue Phytonutrients July 2025):53–71
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J 162750. https://doi.org/10.1155/2013/162750
Li H, Liu Z, Lu H, Chen H (2020) Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach. Cancers 12(12):3749. https://www.mdpi.com/2072-6694/12/12/3749
Liga S, Paul C, Péter F (2023) Flavonoids: Overview of biosynthesis, biological activity, and current extraction techniques. In Sabater-Jara Ana Belén, Lorena Almagro (eds) Plants Vol 12, p 2732. https://doi.org/10.3390/plants12142732
Link A, Balaguer F, Goel A (2010) Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol 80(12):1771–1792. https://doi.org/10.1016/j.bcp.2010.06.036
Liskova A, Koklesova L, Samec M, et al (2020) Flavonoids in cancer metastasis. Cancers 12:1498. https://doi.org/10.3390/cancers12061498
Maharjan PM, Bains S, Lale PK, Bhargava P, Gautam RK (2022) An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway. Phytother Res 36(2):705–728. https://pubmed.ncbi.nlm.nih.gov/34747065/
Marzocchella L, Fantini M, Benvenuto M, Masuelli L, Tresoldi I, Modesti A, Galvano F (2011) Dietary flavonoids: molecular mechanisms of action as anti-inflammatory agents. Recent Pat Inflamm Allergy Drug Discov 5(3):200–220
Maurya AK, Vinayak M (2015) The natural flavonoid fisetin inhibits cellular proliferation of hepatic, colorectal, and pancreatic cancer cells through modulation of multiple signaling pathways. PLoS ONE 10(7):e0132367. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132367
Meer N, Elamin A, Mohammed F, Bashir F, Tayyem R (2026) Dietary polyphenols as anticancer agents: a review of recent advances and mechanisms. Nutr Health 02601060251411197. https://doi.org/10.1177/02601060251411197
MishraRR(2024) Phytochemical analysis and comparison of some selected plants. Vegetos 1–12. https://doi.org/10.1007/s42535-024-01062-4
Mitek M, Mitek M, Majdan M (2020) The role of flavonoids in cancer prevention and therapy: the current state of knowledge. Nutrients 12(6):1604. https://www.mdpi.com/2072-6643/12/6/1604
Murota K, Nakamura Y, Uehara M (2018) Flavonoid metabolism: the interaction of metabolites and gut microbiota. Biosci Biotechnol Biochem 82(4):600–610
Niharika, Parveen R, Parveen B, Umar S, Ahmad S (2026) A comprehensive review on indigenous therapeutic approaches in kidney care using Ayush medicine. Front Pharmacol 16:1588424. https://doi.org/10.3389/fphar.2025.1588424
Nowakowska Z (2007) A review of anti-infective and anti-inflammatory chalcones. Eur J Med Chem 42(2):125–137. https://doi.org/10.1016/j.ejmech.2006.09.019
Okamoto D, Anantharaman A (2025) Comprehensive cancer care and lifestyle medicine. lifestyle medicine: closing research, practice, and knowledge gaps. Springer Nature Switzerland, Cham, pp 299–324
Pal A, Goel F, Sharma A, Garg VK (2025) Oxidative stress and antioxidant therapeutics in autism spectrum disorder: a biochemical and structure–activity relationship perspective. Mol Diversity 1–19
Pan X, Tang S, Gong X, Yu J, Jiang S, Su Y, Li Y (2020) Anti-inflammatory activity of flavonoids in cancer: a review. Frontiers in Pharmacology 11:1025. https://www.frontiersin.org/articles/10.3389/fphar.2020.01025/full
Pandey P, Lakhanpal S, Mahmood D, et al (2025) An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway. Front Pharmacol 15:p1513422
Petersen K, Mansell TJ (2025) Unveiling the prebiotic potential of polyphenols in gut health and metabolism. Curr Opin Biotechnol 95:103338
Ponte LGS, Pavan ICB, Mancini MCS et al (2021) The hallmarks of flavonoids in cancer. In: Francesca Giampieri (ed), Molecules Vol 26, p 2029. https://doi.org/10.3390/molecules26072029
Prasad S, Gupta SC, Tyagi AK, Aggarwal BB (2010) Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv 32(6):1053–1064. https://doi.org/10.1016/j.biotechadv.2014.04.004
Pratheeshkumar P, Budhraja A, Son YO et al (2012) Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS ONE 7(10):e47516. https://doi.org/10.1371/journal.pone.0047516
Pyo Y, Kwon KH, Jung YJ (2024) Anticancer potential of flavonoids: their role in cancer prevention and health benefits. Foods 13(14):2253. https://doi.org/10.3390/foods13142253
Ramprasath LM, Sankar A (2020) Phytochemical insights into flavonoids in cancer: mechanisms, therapeutic potential, and the case of quercetin. Biomed Pharmacother 121:109590. https://pubmed.ncbi.nlm.nih.gov/31756543/
Rao MJ, Zheng B (2025) The role of polyphenols in abiotic stress tolerance and their antioxidant properties to scavenge reactive oxygen species and free radicals. Antioxidants 14(1):74
Rauf A, Imran M, Khan H, Shah M, Hassan SZ (2018) Fisetin: A dietary flavonoid with multi-targeted health benefits. Chemico-Biol Interact 279:16–24. https://pubmed.ncbi.nlm.nih.gov/29080646/
Ren W, Qiao Z, Wang X, Zhu L (2018) The hallmarks of flavonoids in cancer. Antioxidants 7(12):177. https://www.mdpi.com/2076-3921/7/12/177
Romagnolo DF, Selmin OI (2012) Flavonoids and cancer prevention: a review of the evidence. J Nutr Gerontol Geriatr 31(3):206–238. https://doi.org/10.1080/21551197.2012.702534
Speisky H, Shahidi F, Costa de Camargo A, Fuentes J (2022) Revisiting the oxidation of flavonoids: loss, conservation or enhancement of their antioxidant properties. Antioxid (Vol 11:133. https://doi.org/10.3390/antiox11010133
Rostampour K, Alipour K, Mirjalili F, et al (2025) Dietary flavonoids and lung cancer: a GRADE-assessed systematic review and meta-analysis of observational studies. Nutr Cancer 77(2):164–178
Roy P, Amita T, Neha G (2019) Flavones: six selected flavones and their related signaling pathways that induce apoptosis in cancer. Nutr Cancer 71(6):920–942. https://pubmed.ncbi.nlm.nih.gov/31206148/
Russo GL, Tedesco I, Spagnuolo C, Russo M (2012) Antioxidant polyphenols in cancer treatment: friend, foe or foil? Sem Cancer Biol 22(4):303–311. https://doi.org/10.1016/j.semcancer.2012.03.002
Sak K (2016) Cytotoxicity of flavonoids and their derivatives against cancer cells: a review. Toxicol In Vitro 34:148–163. https://pubmed.ncbi.nlm.nih.gov/27040445/
Serafini M, Peluso I, Raguzzini A (2010) Flavonoids as anti-inflammatory agents. Proc Nutr Soc 69(3):273–278. https://doi.org/10.1017/S002966511000162X
Shan F, Liu L, Li L, Wang W, Bi Y, Li M (2025) Management, safety, and efficacy evaluation of nutraceutical and functional food: a global perspective. Compr Rev Food Sci Food Saf 24(4):e70222
Sharma G, Taliyan R, Kumar R (2023) Flavonoids as promising natural compounds against cancer: recent trends and future perspectives. J Funct Foods 100:105370. https://pubmed.ncbi.nlm.nih.gov/36698642/
Sharma H, Anand A, Halagali P et al (2024) Advancement of nanoengineered flavonoids for chronic metabolic diseases. Role Flavonoids Chronic Metabolic Diseases: Bench Clin 459–510
Silva-Pinto PA, de Pontes JTC, Aguilar-Morón B et al (2025) Phytochemical insights into flavonoids in cancer: mechanisms, therapeutic potential, and the case of quercetin. Heliyon 11(4)
Singh A, Kaur P, Kumar M et al (2025) The role of phytochemicals in modulating the gut microbiota: implications for health and disease. Med Microecology 100125
Singh S, Goswami N, Kumar A, Gautam RK (2022) Flavonoids as promising molecules in the cancer therapy: an insight. Food Chem Toxicol 166:113175. https://pubmed.ncbi.nlm.nih.gov/35764350/
Singh A, Singh J, Parween G, Khator R, Monga V (2024) A comprehensive review of apigenin a dietary flavonoid: biological sources, nutraceutical prospects, chemistry and pharmacological insights and health benefits. Crit Rev Food Sci Nutr 1–37
Stachelska MA, Karpiński P, Kruszewski B (2025) A comprehensive review of biological properties of flavonoids and their role in the prevention of metabolic, cancer and neurodegenerative diseases. Appl Sci 15(19):10840. https://doi.org/10.3390/app151910840
Sun J, Sha M, Zhou J, Huang Y (2025) Quercetin affects apoptosis and autophagy in pediatric acute myeloid leukaemia cells by inhibiting PI3K/AKT signaling pathway activation through regulation of miR-224-3p/PTEN axis. BMC Cancer 25(1):318
Tang S, Wang B, Liu X, et al (2025) Structural insights and biological activities of flavonoids: implications for novel applications. Food Front 6(1):218–247
Tiwari R, Mondal Y, Bharadwaj K, Mahajan M, Mondal S, Sarkar A (2025) Reactive oxygen species (ROS) and their profound influence on regulating diverse aspects of cancer: a concise review. Drug Dev Res 86(4):e70107
Tufail T, Fatima S, Ul Ain B, et al (2025) Role of phytonutrients in the prevention and treatment of chronic diseases: a concrete review. ACS omega 10(13):12724–12755
Tumilaar SG, Hardianto A, Dohi H, Kurnia D (2024) A comprehensive review of free radicals, oxidative stress, and antioxidants: overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds. J Chem 20241:5594386
Ullah A, Munir S, Badshah SL et al (2020) Important flavonoids and their role as a therapeutic agent. Molecules. https://doi.org/10.3390/molecules25225243
Vo HVT, Patton GN, Kim SJ, Kim N, Lee HJ (2025) Exploring flavonoids as regulators of NF--2 and MMP‐9 in cancer pathogenesis. Chem Biol Drug Des 105(6):e70145
Wilson AJ, Chueh AC, Tögel L, Corner GA, Young GP (2016) Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. Cancer Res 70(2):609–620
Yi M, Wu X, Zhuang W, Xia L, Chen Y, Mai W (2017) Dietary flavonoids and the risk of gastric cancer: a meta-analysis. PLoS ONE 12(2):e0171974. https://doi.org/10.1371/journal.pone.0171974
You AJ, Park J, Shin JM, Kim TH (2025) Oxidative stress and dietary antioxidants in head and neck cancer. Antioxidants 14(5):508
Yue M, Liu Y, Feng X, Cao B, Fei X, Li G, Li C (2025) Epimedii folium flavonoids: a double-edged sword effect on the liver, a dual exploration of efficacy and toxicity. J Pharm Anal. 101269
Zawawi NA, Ahmad H, Madatheri R, Fadilah NIM, Maarof M, Fauzi MB (2025) Flavonoids as natural anti-inflammatory agents in the atopic dermatitis treatment. Pharmaceutics 17(2):261. https://doi.org/10.3390/pharmaceutics17020261
Zeng Y, Lu X, Wang Y, He J, Cao H, Zhang L, Cheng L (2025) Recent status and trends regarding oxidative stress in gliomas (2013–2025): a systematic review and bibliometric analysis. Front Oncol 15:1586515
Zhang W, Chen T (2021) Flavonoids and Wnt/β-catenin signaling pathway in cancer: a systematic review. Front Pharmacol 12:658603. https://www.frontiersin.org/articles/https://doi.org/10.3389/fphar.2021.658603/full
Zheng J, Yang B, Huang Y, Li S, Wang S, Tang G (2017) Flavonoid intake and cancer risk: a systematic review and meta-analysis of cohort studies. Nutr Cancer 69(8):1115–1127. https://pubmed.ncbi.nlm.nih.gov/28901844/
Zheng X, Zhang X, Zeng F (2025) Biological functions and health benefits of flavonoids in fruits and vegetables: a contemporary review. Foods 14(2):155
Zverev YF, Rykunova AY (2022) Modern nanocarriers as a factor in increasing the bioavailability and pharmacological activity of flavonoids. Appl Biochem Microbiol 58(9):1002–1020
Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J NutritionalScience 5:e47. https://doi.org/10.1017/jns.2016.41
Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. Phytochemistry 55(6):481–504. https://doi.org/10.1016/S0031-9422(00)00235-1
Hollman PCH, Katan MB (1999) Dietary flavonoids: intake, health effectsand bioavailability. Food Chem Toxicol 37(9–10):937–942. https://doi.org/10.1016/S0278-6915(99)00079-4
Messina M (2014) Soy foods,isoflavones, and the health of postmenopausal women. Am J Clin Nutr 100:423S–430S. https://doi.org/10.3945/ajcn.113.071464
Williamson G, Kay CD, Crozier A (2018) The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective. Compr Rev FoodSci Food Saf 17:1054–1112. https://doi.org/10.1111/1541-4337.12351
Selma MV, Espín JC, Tomás-Barberán FA (2009) Interaction between phenolicsand gut microbiota: role in human health. J Agric Food Chem 57(15):6485–6501. https://doi.org/10.1021/jf902107d
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Amity Institute of Microbial Technology, Amity University Rajasthan, Jaipur, India