Vegetos

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Research Articles | Published: 25 May, 2025

References

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Abbasi BH, Zahir A, Ahmad W, Nadeem M, Giglioli-Guivarc’h N, Hano C (2019) Biogenic zinc oxide nanoparticles-enhanced biosynthesis of lignans and neolignans in cell suspension cultures of Linum usitatissimum L. Artif Cells Nanomed Biotechnol 47(1):1367–1373. https://doi.org/10.1080/21691401.2019.1596942


Ahmad MA, Javed R, Adeel M, Rizwan M, Ao Q, Yang Y (2020) Engineered ZnO and CuO nanoparticles ameliorate morphological and biochemical response in tissue culture regenerants of candyleaf (Stevia rebaudiana). Molecules 25(6):1356. https://doi.org/10.3390/molecules25061356


Al-Khayri JM, Naik PM (2020) Elicitor-induced production of biomass and pharmaceutical phenolic compounds in cell suspension culture of date palm (Phoenix dactylifera L.). Molecules 25(20):4669. https://doi.org/10.3390/molecules25204669


Arano-Varela H, Cruz-Sosa F, Estrada-Zúñiga ME, Fernández FJ (2020) Effects of phenylalanine and methyl jasmonate on verbascoside production in Buddleja cordata Kunth cell suspension cultures. S Afr J Bot 135:41–49. https://doi.org/10.1016/j.sajb.2020.08.005


Arif Y, Sami F, Siddiqui H, Bajguz A, Hayat S (2020) Salicylic acid in relation to other phytohormones in plant: A study towards physiology and signal transduction under challenging environment. Environ Exp Bot 175:104040. https://doi.org/10.1016/j.envexpbot.2020.104040


Bavi K, Khavari-Nejad RA, Najafi F, Ghanati F (2022) Phenolics and terpenoids change in response to yeast extract and chitosan elicitation in Zataria multiflora cell suspension culture. 3 BiotCch 12(8):163. https://doi.org/10.1007/s13205-022-03235-x


Bhardwaj P, Goswami N, Narula P, Jain CK, Mathur A (2018) Zinc oxide nanoparticles (ZnO NP) mediated regulation of bacosides biosynthesis and transcriptional correlation of HMG-CoA reductase gene in suspension culture of Bacopa monnieri. Plant Physiol Biochem 130:148–156. https://doi.org/10.1016/j.plaphy.2018.07.001


Boisson AM, Gout E, Bligny R, Rivasseau C (2012) A simple and efficient method for the long-term preservation of plant cell suspension cultures. Plant Methods 8:1–12. https://doi.org/10.1186/1746-4811-8-4


Coelho N, Romano A (2022) Impact of chitosan on plant tissue culture: recent applications. Plant Cell Tiss Organ Cult 148(1):1–13. https://doi.org/10.1007/s11240-021-02156-6


Dorrazehi M, Allahdou M, Fakheri BA, Mehravaran L (2024) Elicitation improves the production of bioactive compounds and antioxidant activity in cell suspension culture of Withania coagulans (Stocks) dunal. Russ J Plant Physiol 71:37. https://doi.org/10.1134/S1021443724603835


Fernandes CA, Jesudoss MN, Nizam A, Krishna SBN, Lakshmaiah VV (2023) Biogenic synthesis of zinc oxide nanoparticles mediated by the extract of Terminalia catappa fruit pericarp and its multifaceted applications. ACS Omega 8(42):39315–39328. https://doi.org/10.1021/acsomega.3c04857


Humbal A, Pathak B (2023) Influence of exogenous elicitors on the production of secondary metabolite in plants: a review (“VSI: secondary metabolites”). Plant Stress 8:100166. https://doi.org/10.1016/j.stress.2023.100166


Jeyasri R, Muthuramalingam P, Karthick K, Shin H, Choi SH, Ramesh M (2023) Methyl jasmonate and salicylic acid as powerful elicitors for enhancing the production of secondary metabolites in medicinal plants: an updated review. Plant Cell Tiss Organ Cult 153(3):447–458. https://doi.org/10.1007/s11240-023-02485-8


Karami Z, Emam-Djomeh Z, Mirzaee HA, Khomeiri M, Mahoonak AS, Aydani E (2015) Optimization of microwave assisted extraction (MAE) and soxhlet extraction of phenolic compound from licorice root. J Food Sci Technol 52:3242–3253. https://doi.org/10.1007/s13197-014-1384-9


Kashem MA, Rahman MM (2018) Micropropagation of Coccinia grandis (Linn.) Voigt Through organogenesis. Euro J Biotech Biosci 6(6):63–68


Kashyap K, Parihar S, Shekhawat GS (2023) In vitro establishment of cell suspension culture of Ceropegia bulbosa for improved production of cerpegin content through elicitation of engineered carbon and ZnO nanoparticles. Environ Sci Pollut Res 30(56):118263–118279. https://doi.org/10.1007/s11356-023-29533-2


Khalifa AM, Eid MA, Gaafar RM, Saad-Allah KM, Gad D (2023) Induction of bioactive constituents and antioxidant enzyme activities in Achillea fragrantissima (Forskal) callus cultures using ZnO nanoparticles. In Vitro Cell Dev Biol-Plant 59(6):808–824. https://doi.org/10.1007/s11627-023-10388-8


Khan T, Khan T, Hano C, Abbasi BH (2019) Effects of chitosan and salicylic acid on the production of pharmacologically attractive secondary metabolites in callus cultures of Fagonia indica. Ind Crop Prod 129:525–535. https://doi.org/10.1016/j.indcrop.2018.12.048


Khan MA, Raza A, Yousaf R, Ali H, Darwish H (2024) Impact of zinc oxide nanoparticles on biosynthesis of thymoquinone in cell cultures of Nigella sativa. Plant Nano Biol 10:100109. https://doi.org/10.1016/j.plana.2024.100109


Kim DH, Han SI, Go B, Oh UH, Kim CS, Jung YH, Lee J, Kim JH (2019) 2-methoxy-4-vinylphenol attenuates migration of human pancreatic cancer cells via blockade of fak and akt signaling. Anticancer Res 39(12):6685–6691. https://doi.org/10.21873/anticanres.13883


Kondhare D, Lade H (2017) Phytochemical profile, aldose reductase inhibitory, and antioxidant activities of Indian traditional medicinal Coccinia grandis (L.) fruit extract. 3 Biotech 7(6):378. https://doi.org/10.1007/s13205-017-1013-1


Krishnan N, Singh PK, Devadasan V, Mariappanadar V, Gopinath SC, Chinni SV, Raman P (2024) Enhanced production of actinidine and glaziovine alkaloids from Nardostachys jatamansi (D. Don) DC. through cell suspension culture with elicitors treatment. Process Biochem 138:139–149. https://doi.org/10.1016/j.procbio.2024.01.016


Largia MJV, Shilpha J, Satish L, Swamy MK, Ramesh M (2023) Elicitation: an efficient strategy for enriched production of plant secondary metabolites. In: Swamy MK, Kumar A (eds) Phytochemical genomics. Springer, Singapore, pp 477–497. https://doi.org/10.1007/978-981-19-5779-6_19


Lee HS, Nagy S (1990) Formation of 4-Vinyl Guaiacol in adversely stored orange juice as measured by an improved HPLC method. J Food Sci 55(1):162–163. https://doi.org/10.1111/j.1365-2621.1990.tb06042.x


Li Q, Jia E, Yan Y, Ma R, Dong J, Ma P (2022) Using the strategy of inducing and genetically transforming plant suspension cells to produce high value-added bioactive substances. J Agric Food Chem 70(3):699–710. https://doi.org/10.1021/acs.jafc.1c05712


Mahendran G, Rahman LU (2024) Methyl jasmonate and salicylic acid as powerful elicitors for enhancing the production of secoiridoid glycoside from cell suspension cultures of Enicostema axillare (Poir. ex Lam.) A. Raynal. Plant Cell Tiss Organ Cult 156(3):68. https://doi.org/10.1007/s11240-023-02679-0


Malerba M, Crosti P, Cerana R (2012) Defense/stress responses activated by chitosan in sycamore cultured cells. Protoplasma 249:89–98. https://doi.org/10.1007/s00709-011-0264-7


Murashige T, Skoog F (1962) A revised medium for rapid growth and bio assays with tobacco tissue culture. Physiol Plant 15(3):473–497. https://doi.org/10.1111/j.1399-3054.1962.tb08052.x


Osman NI, Jaafar Sidik N, Awal A (2018) Efficient enhancement of gallic acid accumulation in cell suspension cultures of Barringtonia racemosa L. by elicitation. Plant Cell Tiss Organ Cult 135:203–212. https://doi.org/10.1007/s11240-018-1456-z


Parimelazhagan T (2015) Pharmacological assays of plant-based natural products (71). Springer, Switzerland. https://doi.org/10.1007/978-3-319-26811-8


Parthasarathy SP, Anusuya S, Rajalakshmi S, Megha D, Appunu C, Alagumanian S, Manickavasagam M (2024) Elucidating the efficacy of functionalized multi-walled carbon nanotube in the biogenesis of L-Dopa and antioxidant metabolites in cell cultures of Hybanthus enneaspermus. Plant Physiol Biochem 206:108310. https://doi.org/10.1016/j.plaphy.2023.108310


Parthasarathy SP, Elayaraja D, Archana A, Vignesh S, Sahayarayan JJ, Alagumanian S, Manickavasagam M (2025) Unravelling the influence of precursors and polyamines on L-Dopa bio-fabrication in elicited suspension cells of Hybanthus enneaspermus (L.) F. Muell. Plant Cell Tiss Organ Cult 161(1):3. https://doi.org/10.1007/s11240-025-03023-4


Rajan M, Feba KS, Chandran V, Shahena S, Mathew L (2020) Enhancement of rhamnetin production in Vernonia anthelmintica (L.) Willd. cell suspension cultures by eliciting with methyl jasmonate and salicylic acid. Physiol Mol Biol Plants 26:1531–1539. https://doi.org/10.1007/s12298-020-00829-8


Rawat V, Ghildiyal A, Singh L, Jugran AK, Bhatt ID, Nandi SK, Pande V (2020) Methyl jasmonate induced polyphenols and antioxidant production in callus suspension culture of Nardostachys jatamansi. Plant Biosyst 154(6):851–859. https://doi.org/10.1080/11263504.2019.1701124


Ribeiro IG, Castro TCD, Coelho MGP, Albarello N (2021) Effects of different factors on friable callus induction and establishment of cell suspension culture of Hovenia dulcis (Rhamnaceae). Rodriguésia 72:e00102020. https://doi.org/10.1590/2175-7860202172105


Sathish S, Vasudevan V, Karthik S, Pavan G, Manickavasagam M (2019) Enhanced l-Dopa production from elicited cell suspension culture of Hybanthus enneaspermus (L.) F. Muell Plant Biotechnol Rep 13:613–621. https://doi.org/10.1007/s11816-019-00555-y


Shehzad MA, Khan MA, Ali A, Mohammad S, Noureldeen A, Darwish H, Ali A, Ahmad A, Khan T, Khan RS (2021) Interactive effects of zinc oxide nano particles and different light regimes on growth and silymarin biosynthesis in callus cultures of Silybum marianum L. Artif Cells Nanomed Biotechnol 49(1):523–535. https://doi.org/10.1080/21691401.2021.1946069


Sivanandhan G, Selvaraj N, Ganapathi A, Manickavasagam M (2014) Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One 9(8):e104005. https://doi.org/10.1371/journal.pone.0104005


Srujana S, Bhagat D (2022) Chemical-based synthesis of ZnO nanoparticles and their applications in agriculture. Nanotechnol Environ Eng 7(1):269–275. https://doi.org/10.1007/s41204-022-00224-6


Sun L, Wang Y, Wang R, Wang R, Zhang P, Ju Q, Xu J (2020) Physiological, transcriptomic, and metabolomic analyses reveal zinc oxide nanoparticles modulate plant growth in tomato. Environ Sci Nano 7(11):3587–3604. https://doi.org/10.1039/D0EN00723D


Tamilselvan N, Thirumalai T, Elumalai EK, Balaji R, David E (2011) Pharmacognosy of Coccinia grandis: a review. Asian Pac J Trop Biomed 1(2):S299–S302. https://doi.org/10.1016/S2221-1691(11)60176-7


Thankachan RM, Joy N, Abraham J, Kalarikkal N, Thomas S, Oluwafemi OS (2017) Enhanced photocatalytic performance of ZnO nanostructures produced via a quick microwave assisted route for the degradation of rhodamine in aqueous solution. Mater Res Bull 85:131–139. https://doi.org/10.1016/j.materresbull.2016.09.009


Thiripurasundari U, Rao MV (2012) Indirect organogenesis from nodal explants of Coccinia grandis (L.) Voigt. Indian J Biotechnol 11:352–354


Tripathi S, Sharma S, Suri S, Tiwari K, Tripathi DK, Sharma S (2024) Insights into physiological and molecular responses of plants under metal-nanoparticle stresses. Molecular and physiological insights into plant stress tolerance and applications in agriculture-part 2. Bentham Science Publishers, Netherlands, pp 147–173


Zhu M, Cui Y (2013) Determination of 4-vinylgaiacol and 4-vinylphenol in top-fermented wheat beers by isocratic high performance liquid chromatography with ultraviolet detector. Braz Arch Biol Technol 56:1018–1023. https://doi.org/10.1590/S1516-89132013000600018

 

Author Information

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Department of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathidasan University, Tiruchirappalli, India