Urena lobata L. (Malvaceae): traditional use, phytochemical composition, and pharmacological potential–an updated mini review

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DOI: 10.1007/s42535-026-01623-9
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Keywords: n Urena lobatan , Traditional use, Phytochemistry, Pharmacological activity


Abstract


The Malvaceae family is a significant plant family, not only in terms of economic value, with genera such as Gossypium, Hibiscus, Malva, and Urena, but also for its contributions to traditional medicine and as a food source. Among them, Urena lobata stands out for its substantial benefits to the community, offering economic, medicinal, and nutritional value. Economically, the plant produces durable and environmentally friendly fiber. Historically, it has served as a famine food for African communities and is also considered a safe and nutritious feed for livestock. The most remarkable contribution of Urena lobata lies in its medicinal properties. Traditional remedies have used this plant to treat digestive disorders, colds, asthma, and even as a contraceptive. Scientific studies have investigated its phytochemical composition, revealing a diverse range of compounds, including flavonoids, lignans, megastigmane, sterols, phenolics, and alkaloids. Researches have further validated several traditional medicinal uses through biological activity studies, demonstrating antioxidant, anti-inflammatory, antidiabetic, antifertility, antidepressant, and antidiarrheal properties. This review further consolidates and expands on new aspects regarding the traditional uses, phytochemical composition, and pharmacological activities of U. lobata, while highlighting its potential for effective utilization in the future.

n                     Urena lobatan                  , Traditional use, Phytochemistry, Pharmacological activity


References


Adeloye A, Akinpelu D, Ogundaini OA, Obafemi C (2007) Studies on antimicrobial, antioxidant and phytochemical analysis of Urena lobata leave extract. J Phys Nat Sci 1(2):1–9


Akomolafe GF, Rosazlina R (2023) Evidence of invasion: land use influences the invasion of Urena lobata in the Guinea Savanna ecosystems of Nigeria. Biol Invasions 25(7):2175–2184. https://doi.org/10.1007/s10530-023-03030-6


Ali S (2013) Antioxidant and cytotoxic activities of methanol extract of Urena lobata (L) leaves. Pharm Innov Pharm Innov 2(2):9–14


Antonius A, Pazla R, Putri EM, Negara W, Laia N, Ridla M, Suharti S, Jayanegara A, Asmairicen S, Marlina L, Marta Y (2023) Effectiveness of herbal plants on rumen fermentation, methane gas emissions, in vitro nutrient digestibility, and population of protozoa. Vet World 16(7):1477–1488. https://doi.org/10.14202/vetworld.2023.1477-1488


Awan TH, Chauhan BS, Sta Cruz PC (2014) Influence of environmental factors on the germination of Urena lobata L. and its response to herbicides. PLoS ONE 9(3):e90305. https://doi.org/10.1371/journal.pone.0090305


Babu SS, Madhuri DB, Ali S (2016) A pharmacological review of Urena lobata plant. Asian J Pharm Clin Res 9(2):20–22


Cao DM, Bui AL, Bui LV, Quach PND (2024a) An efficient droplet-vitrification cryopreservation procedure for high imperatorin-yielding hairy root clones of Urena lobata. Cryobiology 118:105186. https://doi.org/10.1016/j.cryobiol.2024.105186


Cao DM, Bui AL, Van Bui L, Quach PND (2024b) Development of an efficient selection procedure for high imperatorin-yielding hairy root clones of Urena lobata L. using morphological and molecular markers. Plant Cell Tissue Organ Cult 159(2):35. https://doi.org/10.1007/s11240-024-02898-z


Cao DM, Vu PTB, Hoang MTT, Bui AL, Quach PND (2020) Developing a sufficient protocol for the enhancement of α-glucosidase inhibitory activity by Urena lobata L. aeroponic hairy roots using exogenous factors, a precursor, and an elicitor. Plants 9(4):548. https://doi.org/10.3390/plants9040548


Dhanapal R, Ratna JV, Gupta M, Sarathchandran I (2012) Preliminary study on antifertility activity of Enicostemma axillare leaves and Urena lobata root used in Indian traditional folk medicine. Asian Pac J Trop Med 5(8):616–622. https://doi.org/10.1016/s1995-7645(12)60127-8


Fagbohun E (2012) Chemical composition and antimicrobial activities of Urena lobata L. (Malvaceae). J Med Plant Res 6(12):2256–2260. https://doi.org/10.5897/JMPR09.233


Handayani N, Gofur A (2018) The potency of pulutan (Urenalobata L.) leaves decoction as antifertility based on its effect on uterine development of Balb C mice (Musmusculus). J Kedokt Hewan 11(4):153–155. https://doi.org/10.21157/j.ked.hewan.v11i4.6261


Islam M, Ibrahim M, Ahsan MQ, Mohi M, Chowdhury M, Hossain M, Rashid M (2012) Phytochemical and pharmacological investigations of Uraria lagopodies DC. and Urena lobata L. Dhaka Univ J Pharm Sci 11(1):65–69. https://doi.org/10.3329/dujps.v11i1.12490


Islam M, Riaz T, Ayatollahi SA, Sharifi-Rad J (2021) Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice. Clin Phytosci 7(1):11. https://doi.org/10.1186/s40816-021-00249-5


Islam M, Uddin M (2017) A revision on Urena lobata L. Int J Med 5(1):126–131. https://doi.org/10.14419/ijm.v5i1.7525


Jia L, A YM, Jing LL, Zhou SA, Kong DY (2011) Three new flavonoid glycosides from Urena lobata. J Asian Nat Prod Res 13(10):907–914. https://doi.org/10.1080/10286020.2011.599802


Jia L, Bi YF, Jing LL, Zhou SA, Kong DY (2010) Two new compounds from Urena lobata L. J Asian Nat Prod Res 12(11):962–967. https://doi.org/10.1080/10286020.2010.510468


Keke C, Nsofor W, Kumabia F, Iloabuchi G, Ejiofor J, Osuagwu O (2023) GCMS and FTIR analysis of ethanol and methanol leave extract of Urena lobata (caesar weed) for bioactive phytochemical constituents. J Drug Deliv Ther 13:99–115. https://doi.org/10.22270/jddt.v13i1.5722


Kumar D, Kumar S, Sahu M, Govindasamy C, Kumar A (2024) Trachelogenin from Urena lobata demonstrates promising potentials against SARS-CoV-2 Mpro (3CL Protease) of Endemic COVID. J King Saud Univ Sci 36(11):103572. https://doi.org/10.1016/j.jksus.2024.103572


Kumar D, Kumar S, Sahu M, Kumar A (2020) Evaluation of pharmacological features and nanoparticle formation by Urena lobata. Haya Saudi J Life Sci 5(10):226–235. https://doi.org/10.36348/sjls.2020.v05i10.006


Kumar D, Kumar S, Sahu M, Pender GC, Govindasamy C, Kumar S, Kumar A (2025) GC-MS identified bioactive compounds of Urena lobata L. demonstrate anti–inflammatory and immunomodulatory potentials against rheumatoid arthritis: an in silico, in vitro and in vivo evaluation. Pharmacol Res-Nat Prod 6:100152. https://doi.org/10.1016/j.prenap.2025.100152


Luo Y, Su C, Ding N, Qi B, Jia F, Xu X, Liu X, Wang J, Wang X, Tu P, Shi S (2019) Lignan glycosides from Urena lobata. Molecules 24(15):2850. https://doi.org/10.3390/molecules24152850


Mathappan R, Krishnan SK, Sujeet S, Tribedi S (2019) Evaluation of antitumor activity of Urena lobata against Ehrlich ascites carcinoma treated mice. Orient Pharm Exp Med 19(1):21–26. https://doi.org/10.1007/s13596-018-0342-x


Mshelia IY, Dalori BM, Hamman LL, Garba S (2013) Effect of the aqueous root extract of Urena lobata (linn) on the liver of albino rat. Res J Appl Sci Eng Technol 5(1):1–6. https://doi.org/10.19026/rjaset.5.5076


Ngueguim FT, Khan MP, Donfack JH, Siddiqui JA, Tewari D, Nagar GK, Tiwari SC, Theophile D, Maurya R, Chattopadhyay N (2012) Evaluation of Cameroonian plants towards experimental bone regeneration. J Ethnopharmacol 141(1):331–337. https://doi.org/10.1016/j.jep.2012.02.041


Nguyen-Pouplin J, Tran H, Tran H, Phan TA, Dolecek C, Farrar J, Tran TH, Caron P, Bodo B, Grellier P (2007) Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam. J Ethnopharmacol 109(3):417–427. https://doi.org/10.1016/j.jep.2006.08.011


Oanh NC, Lam TQ, Tien ND, Hornick JL, Ton VD (2021) Effects of medicinal plants mixture on growth performance, nutrient digestibility, blood profiles, and fecal microbiota in growing pigs. Vet World 14(7):1894–1900. https://doi.org/10.14202/vetworld.2021.1894-1900


Oladele G, Abatan M (2011) Haematological and sperm count changes following exposure to Hyptis suaveolens, Cleome viscose and Urena lobata in rats. Niger Vet J 31(12):170–176. https://doi.org/10.4314/nvj.v31i2.68956


Omonkhua A, Onoagbe I (2011) Evaluation of the long-term effects of Urena lobata root extracts on blood glucose and hepatic function of normal rabbits. J Toxicol Environ Health Sci 3(8):204–213


Omonkhua AA, Onoagbe IO (2012) Long-term effects of three hypoglycaemic plants (Irvingia gabonensis, Urena lobata and Carica papaya) on the oxidative status of normal rabbits. Biokemistri 24(2):82–89


Purnomo Y, Makdasari J, Fatahillah FI (2021) Inhibitory activity of Urena lobata leaf extract on alpha-amylase and alpha-glucosidase: in vitro and in silico approach. J Basic Clin Physiol Pharmacol 32(4):889–894. https://doi.org/10.1515/jbcpp-2020-0430


Purnomo Y, Soeatmadji DW, Sumitro S, Widodo M (2015a) Anti-hiperglycemic effect of Urena lobata leaf extract byinhibition of dipeptidyl peptidase IV (DPP-IV)on diabetic rats. Int J Pharmacogn Phytochem Res 7(5):1073–1079


Purnomo Y, Soeatmadji DW, Sumitro SB, Widodo MA (2015b) Anti-diabetic potential of Urena lobata leaf extract through inhibition of dipeptidyl peptidase IV activity. Asian Pac J Trop Biomed 5(8):645–649. https://doi.org/10.1016/j.apjtb.2015.05.014


Purnomo Y, Soeatmadji DW, Sumitro SB, Widodo MA (2017) Incretin effect of Urena lobata leaves extract on structure and function of rats islet β-cells. J Tradit Complement Med 7(3):301–306. https://doi.org/10.1016/j.jtcme.2016.10.001


Purnomo Y, Tilaqza A (2022) Analgesic and anti-inflammatory activities of Urena lobata L. leaf extract. Indones J Pharm 33(4):566–574. https://doi.org/10.22146/ijp.2145


Quan PM, Van TTH, Lam DT, Phuong DL, Ich CT, Long PQ, Minh PTH (2019) Study on the chemical constituents of Urena lobata growing in Viet Nam. Vietnam J Sci Technol 57(2):162–169. https://doi.org/10.15625/2525-2518/57/2/13019


Sajem AL, Gosai K (2006) Traditional use of medicinal plants by the Jaintia tribes in North Cachar Hills district of Assam, northeast India. J Ethnobiol Ethnomed 2(1):33. https://doi.org/10.1186/1746-4269-2-33


Shelar PA, Gharge VG, Yadav AV (2017) Pharmacognostic evaluation, phytochemical screening and antimicrobial study of leaves extracts of Urena lobata linn. Curr Res Pharm Sci 7(2):40–49. https://doi.org/10.24092/CRPS.2017.070202


Shelke A, Chavan A, Patel K (2024a) Standardization of Urena lobata linn: unveiling pharmacognostical features, preliminary phytochemical analysis and HPTLC fingerprinting. J Nat Remedies 24(8):1809–1820. https://doi.org/10.18311/jnr/2024/44094


Shelke A, Chavan A, Patel K, Patidar N, Parsaila N, Sharma D, Shinde S, Wakchaure R (2024b) Assessment of in vitro antioxidant and analgesic activity of ethyl acetate fraction of Urena lobata leaves. J Nat Remedies 24(5):1083–1090. https://doi.org/10.18311/jnr/2024/36373


Shi XP, Su C, Qi BW, Yang WQ, Wu Y, Ding N, Dong XJ, Shi S (2017) Flavonoid glycosides from aerial part of Urena lobata. Chin Pharm J 52(19):1670–1674. https://doi.org/10.11669/cpj.2017.19.003


Silalahi M, Supriatna J, Walujo E, Nisyawati N (2015) Local knowledge of medicinal plants in sub-ethnic Batak Simalungun of North Sumatra, Indonesia. Biodiversitas 16(1):44–54. https://doi.org/10.13057/biodiv/d160106


Singh D (2014) Urena lobata: a green source of anti-oxidant. J Plant Sci (Sci Publ Group) 2(6):299. https://doi.org/10.11648/j.jps.20140206.16


Singh D, Singh V (2016) Isolation and characterization of flavonoids in Urena lobata leaves. Eur J Med Plants 11(1):1–6. https://doi.org/10.9734/EJMP/2016/21502


Sipai S, Madhuri DB, D S (2016) Anxiolytic antidepressant and anti-inflammatory activity of ethanolic extract of Urena lobata leaf. Int J Pharm Res Health Sci 4(4):1284–1290. https://doi.org/10.21276/ijprhs.2016.04.07


Su C, Qi B, Wang J, Ding N, Wu Y, Shi X-P, Zhu Z-X, Liu X, Wang X-H, Zheng J, Tu P-F, Shi S-P (2018) Megastigmane glycosides from Urena lobata. Fitoterapia 127:123–128. https://doi.org/10.1016/j.fitote.2018.02.017


Usin S, Okon U, Adedoyin D, Emmanuel P (2024) Evaluation of phytochemical constituents and elemental profiling of selected medicinal plants in South-West, Nigeria. Asian J Biol Sci 17:145–155. https://doi.org/10.3923/ajbs.2024.145.155


Yadav AK, Tangpu V (2007) Antidiarrheal activity of Lithocarpus dealbata and Urena lobata extracts: therapeutic implications. Pharm Biol 45(3):223–229. https://doi.org/10.1080/13880200701213153


Yang Y, Huang Z, Zou X, Zhong X, Liang X, Zhou J (2017) The antibacterial effect of Urena lobata L. fromv Guangxi on mice with Staphylococcus aureus pneumonia. Afr J Tradit Complement Altern Med 14(1):73–88. https://doi.org/10.21010/ajtcam.v14i1.9


Yudi P, Andri T (2024) Inhibitory potential of Pulutan (Urena lobata) leaf extract on inducible nitric oxide synthase as anti-inflammatory agent: in vitro and in silico approaches. Trop J Nat Prod Res 8(8):8195–8201. https://doi.org/10.26538/tjnpr/v8i8.41


Zhou H, Zhang J, Kirbis BS, Mula Z, Zhang W, Kuang Y, Huang Q, Yin L (2023) Ethnobotanical study on medicinal plants used by Bulang people in Yunnan, China. J Ethnobiol Ethnomed 19(1):38. https://doi.org/10.1186/s13002-023-00609-0

 


Author Information


Department of Natural Compounds, Institute of Life Sciences, Vietnam Academy of Science and Technology (VAST), Dalat, Vietnam