Evaluation of different phytochemicals from Cannabis sativa against Myelin oligodendrocyte glycoprotein receptor

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Research Articles | Published:

Print ISSN : 0970-4078.
Online ISSN : 2229-4473.
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Doi: 10.1007/s42535-023-00753-8
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Keywords: Multiple sclerosis, Molecular docking, ADME analysis, Computational biology


Abstract


There is a rapid spread of multiple sclerosis (MS) disorder across the globe. There are around 2.8 million cases of Multiple Sclerosis in the world; among them, 1 million are just present in the US. Many drugs have been tested on MS patients but there is no effective treatment for MS till now. Many agonists, such as dronabinol, and nabilone, have been used to treat MS. So, in this study, different compounds from Cannabis sativa to inhibit the symptoms caused by MS had been evaluated. This study targeted the Myelin oligodendrocyte glycoprotein receptor as it has shown some good results in experimental labs. In this study, binding interactions through the molecular docking model was evaluated which provides insight into possible treatments for MS during interactions between various cannabinoids and MS receptors.


Multiple sclerosis, Molecular docking, ADME analysis, Computational biology


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Acknowledgements



Author Information


Roy Arpita
Department of Biotechnology, Sharda School of Engineering and Technology, Sharda University, Greater Noida, India
arbt2014@gmail.com
Gupta Aaryan
Department of Biotechnology, Sharda School of Engineering and Technology, Sharda University, Greater Noida, India


Verma Devvret
Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, India