Vegetos
(An International Journal of Plant Research & Biotechnology)
Bibliometric analysis of chemometric research applied to phytomedicine: ensuring quality control of medicinal plants
*Article not assigned to an issue yet
Benomar Abdelhafid, Salime Ghita Meknassi, Mabrouki Meryem, Fekrouni Mohamed, Chahboune Rajae, Bouatia Mustapha
Research Articles | Published: 15 July, 2025
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Keywords: Chemometric methods, Quality control, Medicinal plants, Phytomedicine, Spectroscopic analysis, Chromatography
Abstract
Phytomedicine, a vital source of new therapies, is gaining attention for its potential in developing effective and safe drugs. However, ensuring the quality of medicinal plants remains a significant challenge, necessitating advanced approaches like chemometrics. This study conducted a bibliometric analysis on the application of chemometric methods to the quality control of medicinal plants and phytomedicines, aiming to identify publication trends, key topics, collaborations, and future opportunities. Bibliometric data were collected from the PubMed, Scopus, and Web of Science databases, covering the period from 1994 to 2024. 991 articles were included in the analysis using Bibliometrix software. Results indicate a significant rise in publications since 2003, driven by major contributor including China, Sweden, Japan, Korea and Netherlands, with major international collaborations involving Italy, the United States, and South Africa. Research primarily focuses on chemometrics, spectroscopic analysis, chromatography, and quality control of bioactive compounds and plant protection products. Persistent challenges include the absence of harmonized global regulations and risks of product falsification. This study offers a comprehensive overview of current trends in phytomedicine research, emphasizing the pivotal role of ethnopharmacology and chemometric methods in identifying new therapeutic agents. Future directions include fostering stronger international collaborations, particularly with leading nations like China, and adopting advanced technologies such as next-generation sequencing and DNA barcoding to enhance the safety, efficacy, and quality of herbal medicines.
References
Abdelshafy Mohamad OA, Liu Y-H, Huang Y, Kuchkarova N, Dong L, Jiao J-Y, Fang B-Z, Ma J-B, Hatab S, Li W-J (2024) Metabonomic analysis to identify exometabolome changes underlying antifungal and growth promotion mechanisms of endophytic Actinobacterium Streptomyces albidoflavus for sustainable agriculture practice. Front Microbiol 15.. Frontiers Media SA. https://doi.org/10.3389/fmicb.2024.1439798
Alamah Z, AlSoussy I, Fakih A (2023) The role of international research collaboration and faculty related factors in publication citations: evidence from Lebanon. Economies 11(3):90. https://doi.org/10.3390/economies11030090
Andriana Y, Meina LN, Fajriani NA, Fadhilah N, Sefrienda AR, Jasmadi J, Setiaboma W, Andriansyah RCE, Apriyati E, Wanita YP, Setiyoningrum F, Indrasari SD, Sunaryanto R (2023) Chemometric analysis based on GC-MS chemical profiles of essential oil and extracts of black cumin (Nigella sativa L.) and their antioxidant potentials. J Appl Pharm Sci 13(12):214–222.. Open Science Publishers LLP Inc. https://doi.org/10.7324/JAPS.2023.151774
Aria M, Cuccurullo C (2017) Bibliometrix: an R-tool for comprehensive science mapping analysis. J Informetrics 11(4):959–975. https://doi.org/10.1016/j.joi.2017.08.007
Arruda H, Silva ER, Lessa M, Proença D Jr., Bartholo R (2022) VOSviewer and bibliometrix. J Med Libr Association 110(3):392–395. https://doi.org/10.5195/jmla.2022.1434
Atta NH, Handoussa H, Klaiber I, Hitzmann B, Hanafi RS (2023) Chemometric Approach for Profiling of Metabolites of Potential Antioxidant Activity in Apiaceae Species Based on LC-PDA-ESI-MS/MS and FT-NIR. In Separations (Vol. 10, Issue 6). MDPI. https://doi.org/10.3390/separations10060347
Balekundri A, Mannur V (2020) Quality control of the traditional herbs and herbal products: A review. Future J Pharm Sci 6(1):67. https://doi.org/10.1186/s43094-020-00091-5
Biagi D, Nencioni P, Valleri M, Calamassi N, Mura P (2021) Development of a near infrared spectroscopy method for the in-line quantitative Bilastine drug determination during pharmaceutical powders blending. J Pharm Biomed Anal 204:114277. https://doi.org/10.1016/j.jpba.2021.114277
Bukar UA, Sayeed MS, Razak SFA, Yogarayan S, Amodu OA, Mahmood RAR (2023) A method for analyzing text using VOSviewer. MethodsX 11:102339. https://doi.org/10.1016/j.mex.2023.102339
Cendana M, Kuo R-J (2024) Categorical data clustering: A bibliometric analysis and taxonomy. Mach Learn Knowl Extr 6(2):1009–1054. https://doi.org/10.3390/make6020047
Chakole CM (2024) Standardisation and evaluation methods for traditional medicinal plants. In Dr. R. Maurya, Mr. T. Boini, Mr. L. Misro, & Mrs. T. Radhakrishnan (Eds.), Futuristic Trends in Herbal Medicines and Food Products (pp. 93–102). Iterative International Publishers, Selfypage Developers Pvt Ltd. https://doi.org/10.58532/nbennurch245
Dong Y, Toume K, Zhu S, Shi Y, Tamura T, Yoshimatsu K, Komatsu K (2023) Metabolomics analysis of peony root using NMR spectroscopy and impact of the preprocessing method for NMR data in multivariate analysis. J Nat Med 77(4):792–816. Springer. https://doi.org/10.1007/s11418-023-01721-x
Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM (2021) How to conduct a bibliometric analysis: an overview and guidelines. J Bus Res 133:285–296. https://doi.org/10.1016/j.jbusres.2021.04.070
Forsberg J, Nielsen PM, Engelsen SB, Sørensen KM (2021) On-Line Real-Time monitoring of a rapid enzymatic oil degumming process: A feasibility study using Free-Run Near-Infrared spectroscopy. Foods 10(10):2368. https://doi.org/10.3390/foods10102368
Gaião Calixto M, Alves Ramos H, Veríssimo LS, Alves D, Medeiros VD, Fernandes ACA, F. H., Veras G (2023) Trends and application of chemometric pattern recognition techniques in medicinal plants analysis. Crit Rev Anal Chem 53(2):326–338. https://doi.org/10.1080/10408347.2021.1953370
Gao Y, Shi S, Ma W, Chen J, Cai Y, Ge L, Li L, Wu J, Tian J (2019) Bibliometric analysis of global research on PD-1 and PD-L1 in the field of cancer. Int Immunopharmacol 72:374–384. https://doi.org/10.1016/j.intimp.2019.03.045
Ghorbani BD (2024) Bibliometrix: Science Mapping Analysis with R Biblioshiny Based on Web of Science in Applied Linguistics. In H. Meihami & R. Esfandiari (Eds.), A Scientometrics Research Perspective in Applied Linguistics (pp. 197–234). Springer Nature Switzerland. https://doi.org/10.1007/978-3-031-51726-6_8
Glänzel W (2003) Bibliometrics as a research field: A course on theory and application of bibliometric indicators. Course Handouts
Govindaraghavan S, Sucher NJ (2015) Quality assessment of medicinal herbs and their extracts: Criteria and prerequisites for consistent safety and efficacy of herbal medicines Epilepsy Behav 52:363–371. https://doi.org/10.1016/j.yebeh.2015.03.004
Hariyanto R (2023) Bibliometrix Analysis: Management Inventory dan Supply Management| eCo-Fin. https://jurnal.kdi.or.id/index.php/ef/article/view/870
Jha SK, Chauhan S, Lal G (2024) Medicinal properties of plants used in traditional medicinal systems. In: Dr R, Maurya MT, Boini ML, Misro, Radhakrishnan MT (eds) Futuristic trends in herbal medicines and food products. Iterative International Publishers, Selfypage Developers Pvt Ltd, pp 13–56. https://doi.org/10.58532/nbennurch242
Kumar S, Jaiswal AK, Aggarwal M, Ekbbal R, Gaurav G, G (2023) A review on quality control aspects of Indian medicinal plants. Pharmacogn Rev 17(34):276–286. https://doi.org/10.5530/phrev.2023.17.7
Länger R, Stöger E, Kubelka W, Helliwell K (2018) Quality standards for herbal drugs and herbal drug preparations– appropriate or improvements necessary? Planta Med 84(06/07):350–360. https://doi.org/10.1055/s-0043-118534
Leong F, Hua X, Wang M, Chen T, Song Y, Tu P, Chen X-J (2020) Quality standard of traditional Chinese medicines: comparison between European pharmacopoeia and Chinese pharmacopoeia and recent advances. Chin Med 15(1):76. https://doi.org/10.1186/s13020-020-00357-3
Liu C, Zuo Z, Xu F, Wang Y (2023) Authentication of herbal medicines based on modern analytical technology combined with chemometrics approach: A review. Crit Rev Anal Chem 53(7):1393–418. Taylor and Francis Ltd. https://doi.org/10.1080/10408347.2021.2023460
Liu Z, Yang MQ, Zuo Y, Wang Y, Zhang J (2022) Fraud detection of herbal medicines based on modern analytical technologies combine with chemometrics approach: A review. Crit Rev Anal Chem 52(7):1606–1623. https://doi.org/10.1080/10408347.2021.1905503
Mamadaminova Dilnoza (2023) BIOLOGICALiological properties of medicinal herbs:a comprehensive overview. Am J Biomedical Sci Pharm Innov 3(10):10–16. https://doi.org/10.37547/ajbspi/Volume03Issue10-03
Maree J, Kamatou G, Gibbons S, Viljoen A, Van Vuuren S (2014) The application of GC–MS combined with chemometrics for the identification of antimicrobial compounds from selected commercial essential oils. Chemometr Intell Lab Syst 130:172–181. https://doi.org/10.1016/j.chemolab.2013.11.004
McBurney MK, Novak PL (2002) What is bibliometrics and why should you care? Proceedings. IEEE International Professional Communication Conference, 108–114. https://doi.org/10.1109/IPCC.2002.1049094
Peng X, Yu X, Lu L, Ye X, Zhong L, Hu W, Chen S, Song Q, Cai Y, Yin J (2025) Application of handheld near infrared spectrometer in quality control of traditional Chinese medicine: rapid screening and quantitative analysis of lonicerae japonicae Flos adulteration. Spectrochimica Acta - Part A: Mol Biomol Spectrosc 326. Scopus https://doi.org/10.1016/j.saa.2024.125215
Rebiai A, Seghir BB, Hemmami H, Zeghoud S, Amor IB, Kouadri I, Messaoudi M, Pasdaran A, Caruso G, Sharma S, Atanassova M, Pohl P (2022) Quality assessment of medicinal plants via chemometric exploration of quantitative NMR data: A review. Compounds 2(2):163–181. https://doi.org/10.3390/compounds2020012
Rogushina J, Gladun A (2021) Development of domain thesaurus as a set of ontology concepts with use of semantic similarity and elements of combinatorial optimization. Probl Program 003–015. https://doi.org/10.15407/pp2021.02.003
Vainashi R, Amol W, Dighe (n.d.). A Review on Quality control and Standardization of herbals (2022)| Vaishnavi R Warhade| 1 Citations. Retrieved November 18, 2024, https://typeset.io/papers/a-review-on-quality-control-and-standardization-of-herbals-jt6ld10w
Van Eck NJ, Waltman L (2010) Software survey: vosviewer, a computer program for bibliometric mapping. Scientometrics 84(2):523–538. https://doi.org/10.1007/s11192-009-0146-3
Velez-Estevez A, García-Sánchez P, Moral-Munoz JA, Cobo MJ (2022) Why do papers from international collaborations get more citations? A bibliometric analysis of library and information science papers. Scientometrics 127(12):7517–7555. https://doi.org/10.1007/s11192-022-04486-4
Verpoorte R, Choi YH, Kim HK (2010) Metabolomics: What’s new? Flavour Fragr J 25(3):128–31. https://doi.org/10.1002/ffj.1982
Vončina DB (2009) Chemometrics in analytical chemistry. Nova Biotechnol Et Chim 9(2). https://doi.org/10.36547/nbc.1280
Wang H, Chen Y, Wang L, Liu Q, Yang S, Wang C (2023) Advancing herbal medicine: enhancing product quality and safety through robust quality control practices. Front Pharmacol 14:1265178. https://doi.org/10.3389/fphar.2023.1265178
Wilson ID (2011) (n.d.). High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS)-Based Drug Metabolite Profiling| SpringerLink. Retrieved February 24, 2025, from https://link.springer.com/protocol/https://doi.org/10.1007/978-1-61737-985-7_10#citeas
Wu H-Y, Shaw P-C (2022) Strategies for molecular authentication of herbal products: from experimental design to data analysis. Chin Med 17(1):38. https://doi.org/10.1186/s13020-022-00590-y
Xiao P, He L, Wang L (1984) Ethnopharmacologic study of Chinese rhubarb. J Ethnopharmacol 10:275–293. https://doi.org/10.1016/0378-8741(84)90016-3
Yik MH-Y, Wong VC-WT, Wong T-H, Shaw P-C (2021) HerBChain, a blockchain-based informative platform for quality assurance and quality control of herbal products. J Traditional Complement Med 11(6):598–600. https://doi.org/10.1016/j.jtcme.2021.07.005
Yu J, Wu X, Liu C, Newmaster S, Ragupathy S, Kress WJ (2021) Progress in the use of DNA barcodes in the identification and classification of medicinal plants. Ecotoxicol Environ Saf 208:111691. https://doi.org/10.1016/j.ecoenv.2020.111691
Zhang H, Tan H, Lin B, Yang X, Sun Z, Zhong L, Gao L, Li L, Dong Q, Nie L, Zang H (2023) Improved principal component analysis (IPCA): A novel method for quantitative calibration transfer between different Near-Infrared spectrometers. Molecules 28(1):406. https://doi.org/10.3390/molecules28010406
Zhang Y, Wang Y (2023). Recent trends of machine l e a r n i n g applied to multi-source data of medicinal plants J Pharm Anal 13(12):1388–1407. https://doi.org/10.1016/j.jpha.2023.07.012
Zhou E, Shen Q, Hou Y (2024) Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: A review. Front Pharmacol 15:1181183. https://doi.org/10.3389/fphar.2024.1181183
Zhu S, Liu Q, Qiu S, Dai J, Gao X (2022) DNA barcoding: an efficient technology to authenticate plant species of traditional Chinese medicine and recent advances. Chin Med 17(1):112. https://doi.org/10.1186/s13020-022-00655-y
Zohra T, Ovais M, Khalil AT, Qasim M, Ayaz M, Shinwari ZK (2019) Extraction optimization, total phenolic, flavonoid contents, HPLC-DAD analysis and diverse Pharmacological evaluations of Dysphania ambrosioides (L.) Mosyakin & clemants. Nat Prod Res 33(1):136–142. https://doi.org/10.1080/14786419.2018.1437428
Author Information
Laboratory of Life and Health Science, Faculty of Medicine and Pharmacy, Abdelmalek Essaadi University, Tanger, Morocco